Smoldering (or asymptomatic) multiple myeloma People with a solitary plasmacytoma will have long-term follow-up appointments to ensure they remain in remission. Prognosis with radiation alone is usually excellent, but there is a risk that a solitary plasmacytoma could recur and progress to multiple myeloma. It is commonly treated with radiation therapy and rarely requires surgery. Solitary plasmacytoma is rare, making up only 5% of plasma cell disorders. Blood tests show no anemia or high calcium levels, and kidney function is normal.
With a solitary plasmacytoma, bone imaging (X-rays, positron-emission tomography scan or magnetic resonance imaging ) detects only a single lesion. Solitary plasmacytoma within the bone is normally diagnosed by a biopsy that reveals abnormal plasma cells. Isolated plasmacytoma of the bone can affect any bone, but tends to occur most frequently in the bones along the spinal column. An “extramedullary plasmacytoma” is one that grows outside the bone, while an “isolated plasmacytoma of the bone” is one that grows within the bone. Solitary (or isolated) plasmacytomaĪ single group of malignant myeloma cells (rather than multiple lesions, as in multiple myeloma) is called a “solitary plasmacytoma.” This mass of cells can grow inside or outside of bone. People living with MGUS receive regular checkups to ensure that it does not progress. MGUS usually does not cause any problems or require treatment, but in rare cases (1%-2%), it can develop into multiple myeloma. MGUS occurs in about 1% of the general population.
MGUS is a plasma cell neoplasm diagnosed when a small amount of M protein is detected in the blood, but no other criteria for a solitary plasmacytoma or multiple myeloma diagnosis (such as a tumor, multiple lesions or symptoms) are present. Monoclonal gammopathy of undetermined significance (MGUS) Classification also plays an important role in determining the stage of multiple myeloma. Knowing the classification of your disease is very important in deciding when it is appropriate to begin treatment.
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